A new technology aimed at eliminating genetic disease in newborns would combine the DNA of three people, instead of just two, to create a child, potentially redrawing ethical lines for designer babies.
The process works by replacing potentially variant DNA in the unfertilized eggs of a hopeful mother with disease-free genes from a donor. U.S. regulators today will begin weighing whether the procedure, used only in monkeys so far, is safe enough to be tested in humans.
Because the process would change only a small, specific part of genetic code, scientists say a baby would largely retain the physical characteristics of the parents. Still, DNA from all three — mother, father and donor — would remain with the child throughout a lifetime, opening questions about long-term effects for this generation, and potentially the next. Ethicists worry that allowing pre-birth gene manipulation may one day lead to build-to-order designer babies.